Thyroid hormones and platelet activation in COVID-19 patients.
E ColonnelloA CrinitiE LorussoM CurreliM SantulliA AngeloniL GnessiO GandiniCarla LubranoPublished in: Journal of endocrinological investigation (2022)
Increased platelet activation, as represented by increased MPV, has already been reported to correlate with COVID-19 severity, possibly as a consequence of cytokine release. We demonstrated, in a cohort of 103 patients with COVID-19, that MPV is inversely correlated to TH levels, in particular in the case of ESS, where downregulation of TH axis may occur in case of systemic cytokine inflammation and more severe outcomes (death/ARDS). That ESS itself may directly cause platelet activation, as demonstrated by higher MPV in these patients, is an interesting hypothesis which deserves further investigation.
Keyphrases
- sars cov
- end stage renal disease
- coronavirus disease
- newly diagnosed
- ejection fraction
- chronic kidney disease
- oxidative stress
- acute respiratory distress syndrome
- signaling pathway
- cell proliferation
- extracorporeal membrane oxygenation
- adipose tissue
- intensive care unit
- skeletal muscle
- drug induced
- insulin resistance