Iron deficiency is related to lower muscle mass in community-dwelling individuals and impairs myoblast proliferation.

Joanna Sophia J VinkeAlan R GorterMichele F EisengaWendy A DamPeter van der MeerJacob van den BornStephan J L BakkerMartijn F HoesMartin H de Borst

Published in: Journal of cachexia, sarcopenia and muscle (2023)

In population-dwelling individuals, ID is related to lower muscle mass, independent of haemoglobin levels and potential confounders. ID impaired myoblast proliferation and aerobic glycolytic capacity, and induced markers of myocyte atrophy and apoptosis. These findings suggest that ID contributes to loss of muscle mass.

Keyphrases

community dwelling
iron deficiency
signaling pathway
oxidative stress
diabetic rats
high glucose
endoplasmic reticulum stress
cell cycle arrest
high intensity
drug induced
endothelial cells
climate change
cell proliferation