Dimethyl fumarate prevents cytotoxicity and apoptosis mediated by oxidative stress in human adipose-derived mesenchymal stem cells.
Shima ShekarchiAmaneh Mohammadi RoushandehMehryar Habibi RoudkenarMohammad Hadi BahadoriPublished in: Molecular biology reports (2021)
Our findings indicate that DMF enhances the proliferation capability and viability of hASCs and prevents their apoptosis in harsh stressful microenvironments. However, the applicability of DMF as a cytoprotective factor for the augmentation of hASCs requires in-depth preclinical and clinical studies.
Keyphrases
- oxidative stress
- mesenchymal stem cells
- endoplasmic reticulum stress
- cell cycle arrest
- endothelial cells
- cell death
- dna damage
- ischemia reperfusion injury
- induced apoptosis
- diabetic rats
- signaling pathway
- umbilical cord
- cell therapy
- mouse model
- induced pluripotent stem cells
- stem cells
- soft tissue
- pi k akt
- cell proliferation
- heat shock protein