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IκB kinase thwarts aggregation: Phosphorylating TDP-43 for degradation.

Cha YangYanru LiuFenghua Hu
Published in: The Journal of cell biology (2024)
TDP-43 aggregation is a hallmark of neurodegeneration. In this issue, Iguchi et al. (https://doi.org/10.1083/jcb.202302048) report that IκB kinase (IKK), an important mediator of inflammation, phosphorylates cytoplasmic TDP-43 to promote proteasomal degradation, revealing an unexpected link between inflammation and TDP-43 homeostasis.
Keyphrases
  • amyotrophic lateral sclerosis
  • oxidative stress