Hyssopus officinalis exerts hypoglycemic effects on streptozotocin-induced diabetic rats via modulating GSK-3β, C-fos, NF-κB, ABCA1 and ABGA1 gene expression.
Rehab M Abdel-MegeedSamah A El NewaryMai O KadryHassan Z GhanemRabeh A El-SheshenyHussein A H Said-Al AhlAbdel-Hamid Z Abdel-HamidPublished in: Journal of diabetes and metabolic disorders (2020)
From the data recorded, it could be concluded that H. officinalis exerts a great hypoglycemic potential via modulating C-fos, GSK-3β, NF-κB, TNF-α, ABCA1 and ABCG1 gene expression and signaling pathways and could be considered as an effective candidate for DMT2 treatment.
Keyphrases
- diabetic rats
- signaling pathway
- gene expression
- pi k akt
- oxidative stress
- dna methylation
- induced apoptosis
- epithelial mesenchymal transition
- rheumatoid arthritis
- essential oil
- electronic health record
- big data
- cell proliferation
- inflammatory response
- immune response
- metabolic syndrome
- endothelial cells
- high fat diet
- endoplasmic reticulum stress
- drug induced
- toll like receptor
- cancer stem cells
- nuclear factor
- smoking cessation