The catechol-O-methyltransferase (COMT) Val158Met genotype modulates working memory-related dorsolateral prefrontal response and performance in bipolar disorder.

Kamilla Woznica Miskowiak Hanne Lie KjærstadM M StøttrupA M SvendsenK M DemantL K HoeffdingT M WergeK E BurdickK DomschkeAndré Ferrer Carvalho Eduard VietaM VinbergLars Vedel KessingH R SiebnerJ Macoveanu

Published in: Bipolar disorders (2017)

The association between Val allelic load, dlPFC activity and WM impairment points to a putative role of aberrant PFC dopamine tonus in the cognitive impairments in BD.

Keyphrases

working memory
bipolar disorder
major depressive disorder
transcranial direct current stimulation
attention deficit hyperactivity disorder
prefrontal cortex
tyrosine kinase
uric acid
metabolic syndrome
high frequency