Kif6 regulates cilia motility and polarity in brain ependymal cells.

Maki TakagishiYang YueRyan S Gray Kristen J Verhey John B Wallingford

Published in: bioRxiv : the preprint server for biology (2023)

We found that Kif6 is localized to the axonemes of ependymal cells. In vitro analysis shows that Kif6 moves on microtubules and that its loss mice decrease cilia motility and cilia-driven flow, resulting in hydrocephalus.

Keyphrases

induced apoptosis
cell cycle arrest
biofilm formation
endoplasmic reticulum stress
oxidative stress
metabolic syndrome
subarachnoid hemorrhage
adipose tissue
staphylococcus aureus
multiple sclerosis
brain injury
insulin resistance
pi k akt
high fat diet induced
cerebrospinal fluid