Quantitative 3D microscopy highlights altered von Willebrand factor α-granule storage in patients with von Willebrand disease with distinct pathogenic mechanisms.
Maurice SwinkelsFerdows AtiqPetra E BürgisserJohan A SlotmanAdriaan B HoutsmullerCecilia de HeusJudith KlumpermanFrank W G LeebeekJan VoorbergArend Jan Gerard JansenRuben BieringsPublished in: Research and practice in thrombosis and haemostasis (2021)
Our findings highlight the utility of quantitative imaging approaches in assessing platelet granule content, which may help to better understand VWF storage in α-granules and to gain new insights in the etiology of VWD.