Effects of mavacamten on Ca2+ sensitivity of contraction as sarcomere length varied in human myocardium.

Peter O AwindaYemeserach BishawMarissa WatanabeMaya A GuglinKenneth S Campbell Bertrand C W Tanner

Published in: British journal of pharmacology (2020)

Mavacamten did not eliminate sarcomere length-dependent increases in the Ca2+ sensitivity of contraction in myocardial strips from organ donors at physiological temperature. Drugs that modulate myofilament function may be useful therapies for cardiomyopathies.

Keyphrases

endothelial cells
smooth muscle
left ventricular
protein kinase
induced pluripotent stem cells
drug induced