Severe Coronavirus Disease 2019 (COVID-19) is Associated With Elevated Serum Immunoglobulin (Ig) A and Antiphospholipid IgA Antibodies.

Omar Hasan AliDavid BomzeLorenz RischSilvio D BruggerMatthias PaprotnyMyriam WeberSarah ThielLukas KernWerner C AlbrichPhilipp KohlerChristian R KahlertPietro VernazzaPhilipp K BühlerReto A SchüpbachAlejandro Gómez-MejiaAlexandra M PopaAndreas BergthalerJosef M PenningerLukas Flatz

Published in: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America (2021)

Higher total IgA and IgA-aPL were consistently associated with severe illness. These novel data strongly suggest that a vigorous antiviral IgA response, possibly triggered in the bronchial mucosa, induces systemic autoimmunity.

Keyphrases

coronavirus disease
early onset
sars cov
systemic lupus erythematosus
respiratory syndrome coronavirus
drug induced
machine learning