Azoxystrobin Reduces Oral Carcinogenesis by Suppressing Mitochondrial Complex III Activity and Inducing Apoptosis.

Hui ChenLingyu LiYunping LuYajun ShenMin ZhangLihua GeMin WangJing YangZhenchuan TianXiaofei Tang

Published in: Cancer management and research (2020)

AZOX inhibited the development of oral cancer through specific inhibition of the activity of mitochondrial complex III, which led to ROS accumulation, and MMP decrease, ultimately inducing apoptosis. AZOX may be a novel agent for the prevention and treatment of OSCC.

Keyphrases

oxidative stress
cell death
endoplasmic reticulum stress
cell cycle arrest
dna damage
reactive oxygen species
combination therapy
cell proliferation
pi k akt
replacement therapy