Differential effects of GABAA receptor activation in the prelimbic and orbitofrontal cortices on anxiety.
Trudy A GreenSarah J BaraczNick A EverettKatherine J RobinsonJennifer L CornishPublished in: Psychopharmacology (2020)
This study highlights that activation of GABAARs specifically within the PrL, but not OFC, reduces anxiety behaviours in male rats. This suggests that activity of the PrL plays a more important role than the OFC in the neurobiological mechanisms of unconditioned anxiety and should be targeted for future therapies.