Studying local tumour heterogeneity on MRI and FDG-PET/CT to predict response to neoadjuvant chemoradiotherapy in rectal cancer.
Niels W SchurinkSimon R van KranenMaaike BerbeeWouter van ElmptFrans C H BakersSander RobertiJoost J M van GriethuysenLisa A MinMax J LahayeMonique MaasGeerard L BeetsRegina G H Beets-TanDoenja M J LambregtsPublished in: European radiology (2021)
• Quantification of local tumour texture on pre-therapy FDG-PET/CT and MRI has potential added value compared to global tumour features to predict response to chemoradiotherapy in rectal cancer. • However, when combined with clinical baseline parameters such as cTN-stage, the added value of local texture over global tumour features is limited. • Predictive performance of our optimal model-combining clinical baseline variables with global quantitative tumour features-was encouraging (AUC 0.83), warranting further research in this direction on a larger scale.