Dysferlin Enables Tubular Membrane Proliferation in Cardiac Hypertrophy.
Nora Josefine PaulkeCarolin FleischhackerJustus B WegenerGabriel C RiedemannConstantin CretuMufassra MushtaqNina ZarembaWiebke MöbiusYannik ZühlkeJasper WedemeyerLorenz LiebmannAnastasiia A GorshkovaDaniel Kownatzki-DangerEva WagnerTobias KohlCarolin WichmannOlaf JahnHenning UrlaubKarl ToischerGerd HasenfußTobias MoserJulia PreobraschenskiChristof LenzEva A Rog-ZielinskaStephan E LehnartSören BrandenburgPublished in: Circulation research (2024)
Dysferlin represents a new molecular target in cardiac disease that protects the integrity of tubule-sarcoplasmic reticulum junctional complexes for regulated excitation-contraction coupling and controls TAT network reorganization and tubular membrane proliferation in cardiomyocyte hypertrophy induced by pressure overload.