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RNA sequencing of peripheral blood in amyotrophic lateral sclerosis reveals distinct molecular subtypes: considerations for biomarker discovery.

Natalie GrimaSidong LiuDean SouthwoodLyndal HendenAndrew SmithAlbert LeeDominic B RoweSusan D'SilvaIan P BlairKelly Louise Williams
Published in: Neuropathology and applied neurobiology (2023)
Our findings suggest that peripheral blood RNA-seq can identify diagnostic biomarkers and distinguish molecular subtypes of sALS patients however, its prognostic value requires further investigation.
Keyphrases
  • peripheral blood
  • rna seq
  • single cell
  • end stage renal disease
  • ejection fraction
  • newly diagnosed
  • high throughput
  • small molecule
  • prognostic factors
  • peritoneal dialysis
  • single molecule