RNA sequencing of peripheral blood in amyotrophic lateral sclerosis reveals distinct molecular subtypes: considerations for biomarker discovery.

Natalie GrimaSidong LiuDean SouthwoodLyndal HendenAndrew SmithAlbert LeeDominic B RoweSusan D'SilvaIan P BlairKelly Louise Williams

Published in: Neuropathology and applied neurobiology (2023)

Our findings suggest that peripheral blood RNA-seq can identify diagnostic biomarkers and distinguish molecular subtypes of sALS patients however, its prognostic value requires further investigation.

Keyphrases

peripheral blood
rna seq
single cell
end stage renal disease
ejection fraction
newly diagnosed
high throughput
small molecule
prognostic factors
peritoneal dialysis
single molecule