RNA sequencing of peripheral blood in amyotrophic lateral sclerosis reveals distinct molecular subtypes: considerations for biomarker discovery.
Natalie GrimaSidong LiuDean SouthwoodLyndal HendenAndrew SmithAlbert LeeDominic B RoweSusan D'SilvaIan P BlairKelly Louise WilliamsPublished in: Neuropathology and applied neurobiology (2023)
Our findings suggest that peripheral blood RNA-seq can identify diagnostic biomarkers and distinguish molecular subtypes of sALS patients however, its prognostic value requires further investigation.