Calycosin enhances the bactericidal efficacy of polymyxin B by inhibiting MCR-1 in vitro.

X LiuX SunX DengX LvJianfeng Wang

Published in: Journal of applied microbiology (2020)

The synergistic effect of calycosin combined with polymyxin B against various mcr-1-positive bacterial strains paves the way for future pharmaceutical applications of calycosin in fighting mcr-1-positive bacterial infections.

Keyphrases

escherichia coli
multidrug resistant
klebsiella pneumoniae
gram negative
signaling pathway
current status
drug delivery