Intrinsic Atrial Myopathy Precedes Left Ventricular Dysfunction and Predicts Atrial Fibrillation in Lamin A/C Cardiomyopathy.
Maxime Tremblay-GravelKenzo IchimuraKermshlise PicardYumeko KawanoAnnika M DriesFrancois HaddadNeal K LakdawalaMatthew T WheelerVictoria N ParikhPublished in: Circulation. Genomic and precision medicine (2022)
cardiomyopathy is associated with early intrinsic atrial myopathy reflected by high AF prevalence and reduced LA contractile strain, even in the absence of LV dysfunction and LA dilation. Whether LA strain can be used as a monitoring strategy to detect and mitigate AF complications requires validation.
Keyphrases
- atrial fibrillation
- heart failure
- left atrial
- catheter ablation
- left ventricular
- oral anticoagulants
- left atrial appendage
- late onset
- direct oral anticoagulants
- risk factors
- oxidative stress
- cardiac resynchronization therapy
- percutaneous coronary intervention
- muscular dystrophy
- skeletal muscle
- mitral valve
- hypertrophic cardiomyopathy
- early onset
- aortic stenosis
- smooth muscle
- coronary artery disease