Supportive care for the prevention of nausea, vomiting and anorexia in a phase 1B study of selinexor in advanced cancer patients: an exploratory study.

Rony DevLinda L ZhongAbdulrazzak ZarifaAya A AlbittarLaura RubinSuyu LiuTimothy A YapShalini DalalDavid HuiDaniel D KarpApostolia M TsimberidouSarina A Piha-PaulJordi Rodon AhnertSiqing FuFunda Meric-BernstamAung Naing

Published in: Investigational new drugs (2021)

Prophylactic olanzapine decreased nausea, vomiting and maintained weight over 3 months but did not prevent anorexia in patients receiving selinexor and chemotherapy. Low dose olanzapine was well tolerated but associated with hyperglycemia.

Keyphrases

chemotherapy induced
low dose
healthcare
palliative care
high dose
weight loss
quality improvement
pain management
weight gain
radiation therapy
locally advanced
health insurance
rectal cancer