Impact of Human Milk Oligosaccharides and Probiotics on Gut Microbiome and Mood in Autism: A Case Report.
Luana AldegheriFeras KharratAndrea ContiFabio MonicaFrancesca BusaGiuseppina CampiscianoNunzia ZanottaCarolina CasonManola ComarPublished in: Microorganisms (2024)
Recent evidence has highlighted the role of the gut-brain axis in the progression of autism spectrum disorder (ASD), with significant changes in the gut microbiome of individuals with this condition. This report investigates the effects of probiotics and human milk oligosaccharide (HMO) supplements on the gut microbiome, inflammatory cytokine profile, and clinical outcomes in an ASD adolescent with chronic gastrointestinal dysfunction and cognitive impairment. Following treatment, we observed a decrease in proinflammatory cytokines' concentration alongside Sutterella relative abundance, a bacterium reported to be linked with gastrointestinal diseases. Also, we reported a notable increase in mood stability. The study aims to evaluate the use of gut microbiome-based therapy in selected ASD patients, highlighting its potential to improve related clinical symptoms.
Keyphrases
- autism spectrum disorder
- human milk
- low birth weight
- intellectual disability
- attention deficit hyperactivity disorder
- cognitive impairment
- bipolar disorder
- preterm infants
- sleep quality
- end stage renal disease
- young adults
- mental health
- prognostic factors
- white matter
- physical activity
- resting state
- mesenchymal stem cells
- patient reported outcomes
- blood brain barrier
- wastewater treatment
- combination therapy
- brain injury