Secondary structure changes as the potential H 2 sensing mechanism of group D [FeFe]-hydrogenases.

Ivan VoloshynConrad SchumannPrincess R CabotajeAfridi Zamader Henrik Land Moritz Senger

Published in: Chemical communications (Cambridge, England) (2024)

[FeFe]-hydrogenases function as both H 2 catalysts and sensors. While catalysis is well investigated, details regarding the H 2 sensing mechanism are limited. Here, we relate protein structure changes to H 2 sensing, similar to light-driven bio-sensors. Our results highlight how identical cofactors incorporated in alternative protein scaffolds serve different functions in nature.

Keyphrases

protein protein
low cost
amino acid
binding protein
small molecule
atomic force microscopy
risk assessment
climate change