Oncogenic addiction of Fibrolamellar hepatocellular carcinoma to the fusion kinase DNAJB1-PRKACA.
Christoph NeumayerDenise NgCaroline S JiangAdam QureshiGadi LalazarRoger VaughanSanford M SimonPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2022)
Our results validate DNAJB1-PRKACA as the oncogene in FLC and demonstrate both a continued requirement for the oncogene for tumor growth as well as an oncogenic addiction that can be exploited for targeted therapies. We anticipate our approach will be useful for investigations of other fusion genes in pediatric cancers and spur development of precision therapies.