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Ductular Reactions in Liver Injury, Regeneration, and Disease Progression-An Overview.

Nirmala MavilaMallikarjuna Siraganahalli EshwaraiahJaquelene Kennedy
Published in: Cells (2024)
Ductular reaction (DR) is a complex cellular response that occurs in the liver during chronic injuries. DR mainly consists of hyper-proliferative or reactive cholangiocytes and, to a lesser extent, de-differentiated hepatocytes and liver progenitors presenting a close spatial interaction with periportal mesenchyme and immune cells. The underlying pathology of DRs leads to extensive tissue remodeling in chronic liver diseases. DR initiates as a tissue-regeneration mechanism in the liver; however, its close association with progressive fibrosis and inflammation in many chronic liver diseases makes it a more complicated pathological response than a simple regenerative process. An in-depth understanding of the cellular physiology of DRs and their contribution to tissue repair, inflammation, and progressive fibrosis can help scientists develop cell-type specific targeted therapies to manage liver fibrosis and chronic liver diseases effectively.
Keyphrases
  • liver injury
  • drug induced
  • stem cells
  • liver fibrosis
  • oxidative stress
  • multiple sclerosis
  • editorial comment
  • bone marrow