Genetic Determinants of Trehalose Utilization Are Not Associated With Severe Clostridium difficile Infection Outcome.

In a case-control study of patients with Clostridium difficile infection, we found no statistically significant association between the presence of trehalose utilization variants in infecting C. difficile strains and development of severe infection outcome. These results do not support trehalose utilization conferring enhanced virulence in the context of human C. difficile infections.