Critical Role of the cGAS-STING Pathway in Doxorubicin-Induced Cardiotoxicity.

Wei LuoXiaoyi ZouYidan Wang Zheng DongXinyu WengZhiqiang PeiShuai SongYongchao ZhaoZilun WeiRifeng GaoBeijian ZhangLiwei LiuPei-Yuan BaiJin LiuXiang WangTingwen GaoYang ZhangXiaolei SunHang ChenKai HuShisuo DuAi-Jun Sun Jun-Bo Ge

Published in: Circulation research (2023)

Our findings indicate a critical role of the cardiac EC cGAS-STING pathway in DIC. The cGAS-STING pathway may represent a novel therapeutic target for preventing DIC.

Keyphrases

drug delivery
heart failure
left ventricular
diabetic rats
high glucose
oxidative stress
cancer therapy