Critical Role of the cGAS-STING Pathway in Doxorubicin-Induced Cardiotoxicity.
Wei LuoXiaoyi ZouYidan WangZheng DongXinyu WengZhiqiang PeiShuai SongYongchao ZhaoZilun WeiRifeng GaoBeijian ZhangLiwei LiuPei-Yuan BaiJin LiuXiang WangTingwen GaoYang ZhangXiaolei SunHang ChenKai HuShisuo DuAi-Jun SunJun-Bo GePublished in: Circulation research (2023)
Our findings indicate a critical role of the cardiac EC cGAS-STING pathway in DIC. The cGAS-STING pathway may represent a novel therapeutic target for preventing DIC.