Solitary chemosensory cells producing interleukin-25 and group-2 innate lymphoid cells are enriched in chronic rhinosinusitis with nasal polyps.

Neil N PatelMichael A KohanskiIvy W MainaVasiliki TriantafillouAlan D WorkmanCharles Ching Lick Tong Edward Cheng-Lung KuanJohn V BossoNithin D AdappaJames N PalmerDe'Broski R HerbertNoam A Cohen

Published in: International forum of allergy & rhinology (2018)

These data support SCC and ILC2 expansion as well as increased IL-25 production in nasal polyps and may represent early events in the pathogenesis of CRSwNP. IL-13 stimulates proliferation of SCC in a feed-forward loop, a process that is steroid-sensitive.

Keyphrases

chronic rhinosinusitis
induced apoptosis
cell cycle arrest
signaling pathway
endoplasmic reticulum stress
machine learning
big data