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Targeting HOX-PBX interactions causes death in oral potentially malignant and squamous carcinoma cells but not normal oral keratinocytes.

Christopher PlataisRaghu RadhakrishnanSven Niklander EbenspergerRichard MorganDaniel W LambertKeith David Hunter
Published in: BMC cancer (2018)
Inhibition of HOX-PBX interactions causes selective apoptosis of OSCC/PMOL, indicating selective toxicity that may be useful clinically.
Keyphrases
  • oxidative stress
  • endoplasmic reticulum stress
  • cell cycle arrest
  • low grade
  • signaling pathway