Reduced and Delayed Cerebrovascular Reactivity in Patients with Parkinson's Disease.

Sephira G RymanNicholas ShaffAndrew DoddStephanie NitschkeChristopher WertzKayla JulioGerson Suarez CedenoAmanda DeligtischErik ErhardtHenry LinAndrei VakhtinKathleen L PostonRawan TarawnehSarah Pirio RichardsonAndrew Mayer

Published in: Movement disorders : official journal of the Movement Disorder Society (2023)

PD participants exhibited reduced and delayed cerebrovascular reactivity. This dysfunction may play an important role in chronic hypoxia, neuroinflammation, and protein aggregation, mechanisms that could lead to disease progression. Cerebrovascular reactivity may serve as an important biomarker and target for future interventions. © 2023 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.

Keyphrases

traumatic brain injury
physical activity
current status
endothelial cells
lipopolysaccharide induced
systematic review
amino acid
lps induced
brain injury
drug induced