Embryologic Origin Influences Smooth Muscle Cell Phenotypic Modulation Signatures in Murine Marfan Syndrome Aortic Aneurysm.
Albert J PedrozaAlex R DalalRohan ShadNobu YokoyamaKen NakamuraPaul ChengRobert C WirkaOlivia MitchelMichael BaiocchiWilliam HiesingerThomas QuertermousMichael P FischbeinPublished in: Arteriosclerosis, thrombosis, and vascular biology (2022)
SMCs derived from both SHF and neural crest lineages undergo phenotypic modulation in MFS aneurysm but are defined by subtly distinct transcriptional responses. Enhanced TWIST1 transcription factor activity may contribute to enriched collagen synthetic pathways SHF-derived SMCs in MFS.