Chitosan-Integrated Curcumin-Graphene Oxide/Copper Oxide Hybrid Nanocomposites for Antibacterial and Cytotoxicity Applications.
Anandhavelu SanmugamLogesh Kumar SellappanAbbishek SridharanSwathy ManoharanAnanda Babu SairamAbdulrahman I AlmansourSubha VeerasundaramHyun-Seok KimDhanasekaran VikramanPublished in: Antibiotics (Basel, Switzerland) (2024)
This study deals with the facile synthesis of a single-pot chemical technique for chitosan-curcumin (CUR)-based hybrid nanocomposites with nanostructured graphene oxide (GO) and copper oxide (CuO) as the antibacterial and cytotoxic drugs. The physicochemical properties of synthesized hybrid nanocomposites such as CS-GO, CS-CuO, CS-CUR-GO, and CS-CUR-GO/CuO were confirmed with various advanced tools. Moreover, the in vitro drug release profile of the CS-CUR-GO/CuO nanocomposite exhibited sustained and controlled release during different time intervals. Also, the antibacterial activity of the CS-CUR-GO/CuO hybrid nanocomposite presented the maximum bactericidal effect against Staphylococcus aureus and Escherichia coli pathogens. The hybrid nanocomposites revealed improved cytotoxicity behaviour against cultured mouse fibroblast cells (L929) via cell adhesion, DNA damage, and proliferation. Thus, the chitosan-based hybrid nanocomposites offer rich surface area, biocompatibility, high oxidative stress, and bacterial cell disruption functionalities as a potential candidate for antibacterial and cytotoxicity applications.
Keyphrases
- reduced graphene oxide
- drug delivery
- dna damage
- carbon nanotubes
- oxidative stress
- escherichia coli
- staphylococcus aureus
- drug release
- visible light
- induced apoptosis
- silver nanoparticles
- single cell
- signaling pathway
- endothelial cells
- hyaluronic acid
- stem cells
- risk assessment
- cell therapy
- cell proliferation
- quantum dots
- biofilm formation
- multidrug resistant
- essential oil
- climate change
- pi k akt