Tacrolimus Causes Hypertension by Increasing Vascular Contractility via RhoA (Ras Homolog Family Member A)/ROCK (Rho-Associated Protein Kinase) Pathway in Mice.
Xiaohua WangShan JiangLingyan FeiFang DongLanyu XieXingyu QiuYan LeiJie GuoMing ZhongXiaoqiu RenYi YangLiang ZhaoGensheng ZhangHonghong WangChun TangLuyang YuRuisheng LiuAndreas PatzakPontus B PerssonMichael HultströmQichun WeiEn-Yin LaiZhihua ZhengPublished in: Hypertension (Dallas, Tex. : 1979) (2022)
The RhoA/ROCK pathway may play an important role in tacrolimus-induced hypertension by enhancing Ang II-specific vasoconstriction, and reactive oxygen species may participate in this process by activating the RhoA/ROCK pathway.