Hyperglycaemia induces metabolic reprogramming into a glycolytic phenotype and promotes epithelial-mesenchymal transitions via YAP/TAZ-Hedgehog signalling axis in pancreatic cancer.

Zhao LiuHiromitsu HayashiKazuki MatsumuraYoko OgataHiroki SatoYuta ShiraishiNorio UemuraTatsunori MiyataTakaaki HigashiShigeki NakagawaKosuke MimaKatsunori ImaiHideo Baba

Published in: British journal of cancer (2022)

Hyperglycaemia induces metabolic reprogramming into glycolytic phenotype and promotes EMT via YAP/TAZ-Hedgehog signalling axis, and YAP/TAZ could be a novel therapeutic target in PDAC.

Keyphrases

stem cells
epithelial mesenchymal transition
bone marrow