CYP2D6-guided opioid therapy for adults with cancer pain: a randomized implementation clinical trial.
Scott A MosleyEmily J CicaliAlex Del CuetoDiane G PortmanKristine A DonovanYan GongTaimour Y LangaeePriya GopalanJessica SchmitJason S StarrNatalie SilverYoung D ChangSahana RajasekharaJoshua E SmithHeloisa P SoaresMike Clare-SalzlerPetr StarostikThomas J GeorgeHoward L McLeodRoger B FillingimJ Kevin HicksLarisa H CavallariPublished in: Pharmacotherapy (2023)
Our study revealed high acceptance of pharmacogenetic testing as part of a clinical trial among patients with cancer pain. However, provider response to genotype-guided recommendations was low, impacting assessment of pain-related outcomes. Addressing barriers to utility of pharmacogenetics results and clinical recommendations will be critical for implementation success.