Recent knowledge of NFATc4 in oncogenesis and cancer prognosis.
Qiu-Hua ZhongSi-Wei ZhaAndy T Y LauYan-Ming XuPublished in: Cancer cell international (2022)
Nuclear factor of activated T-cells, cytoplasmic 4 (NFATc4), a transcription factor of NFAT family, which is activated by Ca 2+ /calcineurin signaling. Recently, it is reported that aberrantly activated NFATc4 participated and modulated in the initiation, proliferation, invasion, and metastasis of various cancers (including cancers of the lung, breast, ovary, cervix, skin, liver, pancreas, as well as glioma, primary myelofibrosis and acute myelocytic leukemia). In this review, we cover the latest knowledge on NFATc4 expression pattern, post-translational modification, epigenetic regulation, transcriptional activity regulation and its downstream targets. Furthermore, we perform database analysis to reveal the prognostic value of NFATc4 in various cancers and discuss the current unexplored areas of NFATc4 research. All in all, the result from these studies strongly suggest that NFATc4 has the potential as a molecular therapeutic target in multiple human cancer types.
Keyphrases
- nuclear factor
- transcription factor
- healthcare
- papillary thyroid
- toll like receptor
- squamous cell
- endothelial cells
- emergency department
- squamous cell carcinoma
- liver failure
- bone marrow
- childhood cancer
- gene expression
- signaling pathway
- immune response
- acute myeloid leukemia
- intensive care unit
- acute respiratory distress syndrome
- binding protein
- respiratory failure
- human health
- induced pluripotent stem cells
- soft tissue
- aortic dissection