Hypoxia-enhanced YAP1-EIF4A3 interaction drives circ_0007386 circularization by competing with CRIM1 pre-mRNA linear splicing and promotes non-small cell lung cancer progression.

Lixia LiDewei LiuTingting ChenChunhui WeiYouping QiaoWeiliang LiuYanmei LiangZhu LiangChunyuan ChenDongming LiBin WuXuanna ZhaoDan HuangDong Wu

Published in: Journal of experimental & clinical cancer research : CR (2024)

Circ_0007386, regulated by YAP1-EIF4A3 interaction under hypoxia conditions, plays an oncogenic role in NSCLC progression via the miR-383-5p/CIRBP axis.

Keyphrases

endothelial cells
small cell lung cancer
transcription factor
advanced non small cell lung cancer
epidermal growth factor receptor
brain metastases