A genome-wide genomic score added to standard recommended stratification tools does not improve the identification of patients with very low bone mineral density.

Josephine TherkildsenP D RohdeL NissenJ ThygesenE-M HaugeB L LangdahlM BoettcherM NyegaardS Winther

Published in: Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA (2023)

Our results suggest adding a GS to a CRF model does not improve prediction. However, we noticed that the GS performed equally or above individual risk factors in discrimination. Clinical risk factors combined showed superior discrimination to individual risk factors and the GS, underlining the value of combined CRFs in routine clinics as a stratification tool.

Keyphrases

risk factors
bone mineral density
genome wide
postmenopausal women
body composition
primary care
dna methylation
copy number
gene expression
clinical practice