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License to kill: Retinoic acid programs T cells for tissue residency.

Maximilian HeegAnanda W Goldrath
Published in: The Journal of experimental medicine (2023)
In this issue of JEM, Qiu et al. (2023. J. Exp. Med. https://doi.org/10.1084/jem.20210923) show that retinoic acid signaling during priming in the mesenteric lymph node licenses CD8+ T cells to develop into small intestinal tissue-resident memory cells, a finding that provides key insights into tissue-specific vaccination strategies.
Keyphrases
  • lymph node
  • induced apoptosis
  • cell cycle arrest
  • public health
  • working memory
  • patient safety
  • quality improvement
  • squamous cell carcinoma
  • cell death
  • pi k akt