Structure-Function Relationships of Human Milk Oligosaccharides on the Intestinal Epithelial Transcriptome in Caco-2 Cells and a Murine Model of Necrotizing Enterocolitis.

Richard You Wu Bo LiRachael G HorneAbdalla AhmedDorothy LeeShaiya C RobinsonHaitao ZhuMarissa CadeteMashriq AlganabiRachel FillerKathene C Johnson-HenryPaul Delgado-OlguinAgostino PierroPhilip M Sherman

Published in: Molecular nutrition & food research (2021)

These results demonstrate that while structurally distinct HMOs impact intestinal physiology, their mechanisms of action differ. This finding establishes the first structure-function relationship of HMOs in the context of intestinal cell signaling responses and offers a functional framework by which to screen and design HMO-like compounds.

Keyphrases

human milk
low birth weight
single cell
induced apoptosis
gene expression
rna seq
high throughput
cell cycle arrest
oxidative stress
preterm birth
signaling pathway