Germline and somatic DNA repair gene alterations in prostate cancer.
Marc A Dall'EraJohn D McPhersonAllen C GaoRalph W DeVere WhiteJeffrey P GreggPrimo N LaraPublished in: Cancer (2020)
DNA repair gene mutations are more common in metastatic than localized prostate tumors. Visceral and other solid organ metastases appear enriched for these mutations compared with localized tumors or bone and lymph node metastases.
Keyphrases
- dna repair
- prostate cancer
- lymph node
- dna damage
- radical prostatectomy
- copy number
- dna damage response
- squamous cell carcinoma
- small cell lung cancer
- genome wide
- bone mineral density
- neoadjuvant chemotherapy
- sentinel lymph node
- gene expression
- adipose tissue
- early stage
- dna methylation
- radiation therapy
- skeletal muscle
- genome wide identification
- postmenopausal women
- rectal cancer