Glycaemic control and macrovascular and microvascular outcomes: A systematic review and meta-analysis of trials investigating intensive glucose-lowering strategies in people with type 2 diabetes.
Setor Kwadzo KunutsorVictoria G BalasubramanianFrancesco ZaccardiClare L GilliesVanita R ArodaSamuel SeiduKamlesh Khunti F MedSciPublished in: Diabetes, obesity & metabolism (2024)
In people with T2D, intensive glucose control was associated with a reduced risk of non-fatal MI and several microvascular outcomes, particularly retinopathy and nephropathy. The lack of an effect of intensive glucose-lowering on most macrovascular outcomes calls for a more comprehensive approach to managing cardiovascular risk factors alongside glycaemic control.