Powassan Virus Neuropathology and Genomic Diversity in Patients With Fatal Encephalitis.

Erica NormandinIsaac H SolomonSiavash ZamirpourJacob LemieuxCatherine A FreijeShibani S MukerjiChristopher Tomkins-TinchDaniel ParkPardis C SabetiPardis Sabeti

Published in: Open forum infectious diseases (2020)

We demonstrate the utility of molecular assays for detecting POWV infection, including in seronegative patients, and nominate viral genomic features that may relate to human infection and neuropathogenicity. The cerebellum was identified as a key target POWV in fatal infection, by radiological and histopathological findings as well as molecular testing.

Keyphrases

end stage renal disease
endothelial cells
newly diagnosed
ejection fraction
sars cov
copy number
prognostic factors
single molecule
dna methylation
patient reported