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Patient-Centered Outcomes in ARIEL3, a Phase III, Randomized, Placebo-Controlled Trial of Rucaparib Maintenance Treatment in Patients With Recurrent Ovarian Carcinoma.

Amit M OzaDomenica LorussoCarol AghajanianAna OakninAndrew DeanNicoletta ColomboJohanne I WeberpalsAndrew R ClampGiovanni ScambiaAlexandra LearyRobert W HollowayMargarita Amenedo GancedoPeter C FongJeffrey C GohDavid M O'MalleyDeborah K ArmstrongSusana BanerjeeJesús García-DonasElizabeth M SwisherDavid CellaJuliette MeunierSandra GobleTerri CameronLara MaloneyAnn-Christin MörkJosh BedelJonathan A LedermannRobert L Coleman
Published in: Journal of clinical oncology : official journal of the American Society of Clinical Oncology (2020)
The significant differences in QA-PFS and Q-TWiST confirm the benefit of rucaparib versus placebo in all predefined cohorts.
Keyphrases
  • phase iii
  • double blind
  • placebo controlled
  • open label
  • clinical trial
  • phase ii
  • study protocol
  • epithelial mesenchymal transition
  • adipose tissue
  • combination therapy
  • insulin resistance
  • replacement therapy