The hypervirulent Group B Streptococcus HvgA adhesin promotes central nervous system invasion through transcellular crossing of the choroid plexus.
Eva AznarNathalie StrazielleLionel CostaClaire PoyartAsmaa TaziJean-François Ghersi-EgeaJulie GuignotPublished in: Fluids and barriers of the CNS (2024)
Our findings reveal a GBS strain-specific ability to infect the blood-CSF barrier, which appears to be an important site of bacterial entry and an active site of immune cell trafficking in response to infection.