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Ganotheaecolin A, a Neurotrophic Conjugated Ergosterol with a Naphtho[1,8-ef]azulene Scaffold from Ganoderma theaecolum.

Qi LuoZhu-Liang YangYong-Ming YanYong-Xian Cheng
Published in: Organic letters (2017)
Ganotheaecolin A (1), a novel ergosterol with a rare naphtho[1,8-ef]azulene ring system, was isolated from the fruiting bodies of Ganoderma theaecolum. Its structure was determined by spectroscopic data and computational methods. Compound 1 represents a 6/6/7/5-fused carbon skeletal ergosterol typically formed by Wagner-Meerwein rearrangement, whose plausible biosynthetic pathway was briefly discussed. Finally, the neurotrophic activity of 1 was examined using PC12 cells.
Keyphrases
  • molecular docking
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  • photodynamic therapy
  • big data
  • tissue engineering
  • machine learning
  • deep learning
  • molecular dynamics simulations