When stem cells meet COVID-19: recent advances, challenges and future perspectives.
Shasha LiHecheng ZhuMing ZhaoWeidong LiuLei WangBin ZhuWen XieCong ZhaoYao ZhouCaiping RenHui LiuXingjun JiangPublished in: Stem cell research & therapy (2022)
Coronavirus disease 2019 (COVID-19) caused by the novel severe acute respiratory coronavirus 2 is currently spreading throughout the world with a high rate of infection and mortality and poses a huge threat to global public health. COVID-19 primarily manifests as hypoxic respiratory failure and acute respiratory distress syndrome, which can lead to multiple organ failure. Despite advances in the supportive care approaches, there is still a lack of clinically effective therapies, and there is an urgent need to develop novel strategies to fight this disease. Currently, stem cell therapy and stem cell-derived organoid models have received extensive attention as a new treatment and research method for COVID-19. Here, we discuss how stem cells play a role in the battle against COVID-19 and present a systematic review and prospective of the study on stem cell treatment and organoid models of COVID-19, which provides a reference for the effective control of the COVID-19 pandemic worldwide.
Keyphrases
- coronavirus disease
- stem cells
- sars cov
- cell therapy
- acute respiratory distress syndrome
- public health
- respiratory syndrome coronavirus
- extracorporeal membrane oxygenation
- mechanical ventilation
- healthcare
- respiratory failure
- type diabetes
- chronic pain
- intensive care unit
- working memory
- coronary artery disease
- health insurance