Dual sensing of methionine and aspartic acid in aqueous medium by a quinoline-based fluorescent probe.

C ElamathiRaymond John Butcher Amirthalingam MohankumarP SundararajKuppanagounder P ElangoP KalaivaniRathinasabapathi Prabhakaran

Published in: Dalton transactions (Cambridge, England : 2003) (2021)

A quinoline-based Schiff base sensor, 6-methyl-2-oxo-1,2-dihydro-quinoline-3-carboxaldehyde-4(N)-phenylsemicarbazone (6MPS), has been developed for selective sensing of methionine and aspartic acid in aqueous medium through "on-off-on" type selective detection of copper ion. Fluorescence imaging of 6MPS, 6MPSC, 6MPSCN, 6MPSC-met, 6MPSCN-met, 6MPSC-asp and 6MPSCN-asp has been successfully demonstrated, in which the sensing probes 6MPSC-met, 6MPSCN-met, 6MPSC-asp and 6MPSCN-asp displayed bright green fluorescence in both in vitro and in vivo live cells.

Keyphrases

fluorescence imaging
fluorescent probe
living cells
tyrosine kinase
molecular docking
photodynamic therapy
single molecule
cell cycle arrest
amino acid
cell proliferation
signaling pathway
oxidative stress
real time pcr
loop mediated isothermal amplification
oxide nanoparticles