The Scleroderma Tango: Unraveling the Delicate Dance of Diastolic Dysfunction and Interstitial Lung Disease.
Vivek P JaniMonica MukherjeePublished in: The Journal of rheumatology (2024)
In this issue of The Journal of Rheumatology , Fairley and colleagues investigated the effects of concomitant left ventricular diastolic dysfunction (LVDD) in a small cohort of patients with systemic sclerosis (SSc)-associated interstitial lung disease (ILD) derived from the larger Australian Scleroderma Cohort Study. 1 Consistent with prior reports, the authors found that patients with SSc-ILD with LVDD experienced dyspnea and reduced survival. In addition, these patients were older, had longer SSc disease duration exceeding 6 years, received treatment with immunosuppressive drugs, and had additional cardiovascular (CV) comorbidities.
Keyphrases
- interstitial lung disease
- systemic sclerosis
- left ventricular
- ejection fraction
- rheumatoid arthritis
- aortic stenosis
- end stage renal disease
- idiopathic pulmonary fibrosis
- blood pressure
- newly diagnosed
- oxidative stress
- chronic kidney disease
- heart failure
- hypertrophic cardiomyopathy
- cardiac resynchronization therapy
- physical activity
- mitral valve
- left atrial
- patient reported outcomes
- mass spectrometry
- palliative care
- coronary artery disease
- combination therapy
- replacement therapy
- atomic force microscopy