Gold(I)-Catalyzed 1,3-Carbofunctionalizations of Anthranils with Vinyl Propargyl Esters To Yield 1,3-Dihydrobenzo[ c]-isoxazoles.

This work describes gold-catalyzed 1,3-carbofunctionalizations of anthranils with vinyl propargyl esters to form 1,3-dihydrobenzo[ c]-isoxazoles. Excellent diastereoselectivity has been achieved to yield products containing three stereogenic carbons. These new catalytic reactions are operable with anthranils and vinyl propargyl esters over a wide scope, further manifesting the synthetic utility.