Inhaled nitric oxide prevents NSAID-induced renal impairment in pseudo-normovolaemic piglets.

Stéphane JunotStephanie KeroakJerome R E Del CastilloJean-Yves AyoubChristian PaquetJeanne-Marie Bonnet-GarinEric Troncy

Published in: PloS one (2017)

Our experiments show that iNO, released from its transport forms after its inhalation, can improve renal safety of NSAIDs. This result is promising regarding the use of NSAIDs in critical conditions, but needs to receive clinical confirmation.

Keyphrases

nitric oxide
anti inflammatory drugs
high glucose
cystic fibrosis
hydrogen peroxide
nitric oxide synthase
mouse model
endothelial cells