Association of prestroke metformin use, stroke severity, and thrombolysis outcome.
Laura P WestphalRoni WidmerUlrike HeldKlaus SteigmillerChristian HametnerPeter RinglebSami CurtzeNicolas Martinez-MajanderMarjaana TiainenChristian H NolteJan F ScheitzHebun ErdurAlexandros A PolymerisChristopher TraenkaAshraf EskandariPatrik MichelMirjam Rachel HeldnerMarcel ArnoldAndrea ZiniLaura VandelliJonathan M CoutinhoAdrien E GrootVisnja PadjenDejana R JovanovicYannick BejotCéline BrenièreGuillaume TurcPierre SenersAlessandro PezziniMauro MagoniDidier LeysSixtine GilliotMichael J ScherrerGeorg KägiAndreas R LuftHenrik GensickePaul NederkoornTurgut TatlisumakStefan T EngelterSusanne Wegenernull nullPublished in: Neurology (2020)
Patients with stroke and diabetes on treatment with MET receiving IVT had less severe strokes on admission and a better functional outcome at 3 months. This suggests a protective effect of MET resulting in less severe strokes as well as beneficial thrombolysis outcome.