Mdivi1 ameliorates mitochondrial dysfunction in non-alcoholic steatohepatitis by inhibiting JNK/MFF signaling.

Ying QuanDiwen ShouSiqi YangJiemin ChengYongqiang LiChen HuangHuiting ChenYong Jian Zhou

Published in: Journal of gastroenterology and hepatology (2023)

Collectively, Mdivi1 protected against diet-induced NASH by restoring mitochondrial homeostasis and function, potentially through its inhibitory effect on the JNK/MFF pathway. Consequently, further investigation of Mdivi1 as a promising drug for NASH treatment is warranted.

Keyphrases

signaling pathway
cell death
induced apoptosis
oxidative stress
adverse drug